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If those genes don't work, babies are born with severely small brains, called microcephaly.

Using DNA samples from ethnically diverse populations, they identified a collection of variations in each gene that occurred with unusually high frequency.

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"A different way to look at is it's almost impossible for evolution not to happen." Still, the findings also are controversial, because it's far from clear what effect the genetic changes had or if they arose when Lahn's "molecular clock" suggests — at roughly the same time period as some cultural achievements, including written language and the development of cities.

Lahn and colleagues examined two genes, named microcephalin and ASPM, that are connected to brain size.

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